University of California, San Diego

PUBLICATIONS

Selected Publications

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Infection and cancer suppress pDC derived IFN-I

Greene TT, Jo YR, Zuniga EI. Curr Opin Immunol. 2020 Oct;66:114-122. doi: 10.1016/j.coi.2020.08.001. Epub 2020 Sep 15. PMID: 32947131

CD8 T cells drive anorexia, dysbiosis, and blooms of a commensal with immunosuppressive potential after viral infection.

Labarta-Bajo L, Gramalla-Schmitz A, Gerner RR, Kazane KR, Humphrey G, Schwartz T, Sanders K, Swafford A, Knight R, Raffatellu M, Zúñiga EI.Proc Natl Acad Sci U S A. 2020 Oct 6;117(40):24998-25007. doi: 10.1073/pnas.2003656117. Epub 2020 Sep 21.

Type I IFNs and CD8 T cells increase intestinal barrier permeability after chronic viral infection.

Labarta-Bajo L, Nilsen SP, Humphrey G, Schwartz T, Sanders K, Swafford A, Knight R, Turner JR, Zúñiga EI.J Exp Med. 2020 Dec 7;217(12):e20192276. doi: 10.1084/jem.20192276.

 

DDX3 suppresses type I interferons and favors viral replication during Arenavirus infection

Loureiro ME, Zorzetto-Fernandes AL, Radoshitzky S, Chi X, Dallari S, Marooki N, Lèger P, Foscaldi S, Harjono V, Sharma S, Zid BM, López N, de la Torre JC, Bavari S, Zuniga El.

PLoS Pathog. 2018 Jul 12;14(7):e1007125. doi: 10.1371/journal.ppat.1007125

Self-Renewal and Toll-like Receptor Signaling Sustain Exhausted Plasmacytoid Dendritic Cells during Chronic Viral Infection.

Macal M, Jo Y, Dallari S, Chang AY, Dai J, Swaminathan S, Wehrens EJ, Fitzgerald P, Zuniga EI.

Immunity. 2018 Apr 17: 48(4):730-744.e5. doi:10.1016/j.immuni

Src Family Kinases Fyn and Lyn are Constitutively Activated and Mediate Plasmacytoid Dendritic   Cell Responses.

Dallari S, Macal M, Loureiro ME, Jo Y, Swanson L, Hesser C, Ghosh P, Zuniga EI.

Nat Commun. 2017 Apr 3;8:14830. doi: 10.1038/ncomms14830.

TGF-β Receptor Maintains CD4 T Helper Cell Identity during Chronic Viral Infections.

Lewis GM, Wehrens EJ, Labarta-Bajo L, Streeck H, Zuniga EI.

J Cling Invest. 2016 Oct 3;126(10):3799-3813. doi: 10.1172/JCI87041.

CD28 Deficiency Enhances Type I IFN Production by Murine Plasmacytoid Dendritic Cells.

Macal M, Tam MA, Hesser C, Di Domizio J, Leger P, Gilliet M, Zuniga EI.
J Immunol. 2016 Feb 15;196(4):1900-9. doi: 10.4049/jimmunol.1501658.

Innate and Adaptive Immune Regulation During Chronic Viral Infections.

Zuniga EI, Macal M, Lewis GM, Harker JA.

Annu Rev Virol. 2015 Nov;2(1):573-97. doi: 10.1146/annurev-virology-100114-055226.

Cell-Intrinsic gp130 Signaling on CD4+ T Cells Shapes Long-Lasting Antiviral Immunity

Harker JA, Wong KA, Dolgoter A, Zuniga EI.

J Immunol. 2015 Aug 1;195(3):1071-81. doi: 10.4049/jimmunol.1402402.

Cell-Intrinsic IL-27 and gp130 Cytokine Receptor Signaling Regulates Virus-Specific CD4+ T Cell Responses and Viral Control during Chronic Infection

Harker JA, Dolgoter A, Zuniga EI.

Immunity. 2013 Sep 19;39(3):548-59. doi: 10.1016/j.immuni.2013.08.010.

Plasmacytoid Dendritic Cells are Productively Infected and Activated Through TLR-7 Early after Arenavirus Infection.

Macal M, Lewis GM, Kunz S, Flavell R, Harker JA, Zuniga EI.

Cell Host Microbe. 2012 Jun 14;11(6):617-30. doi: 10.1016/j.chom.2012.04.017.

Late interleukin-6 Escalates T Follicular Helper Cell Responses and Controls a Chronic Viral Infection.

Harker JA, Lewis GM, Mack L, Zuniga EI.

Science. 2011 Nov 11;334(6057):825-9. doi: 10.1126/science.1208421.

Cell-Intrinsic Transforming Growth Factor-β Signaling Mediates Virus-Specific CD8+ T Cell Deletion and Viral Persistence In Vivo.

Tinoco R, Alcalde V, Yang Y, Sauer K, Zuniga EI.

Immunity. 2009 Jul 17;31(1):145-57. doi: 10.1016/j.immuni.2009.06.015.

Persistent Virus Infection Inhibits Type I interferon Production by Plasmacytoid Dendritic Cells to Facilitate Opportunistic Infections.

Zuniga EI, Liou LY, Mack L, Mendoza M, Oldstone MB.

Cell Host Microbe. 2008 Oct 16;4(4):374-86. doi: 10.1016/j.chom.2008.08.016.

Adoptive Immunotherapy Induces CNS Dendritic Cell Recruitment and Antigen Presentation during Clearance of a Persistent Viral Infection.

Lauterbach H, Zuniga EI, Truong P, Oldstone MB, McGavern DB.

J Exp Med. 2006 Aug 7;203(8):1963-75. Epub 2006 Jul 17.

Bone Marrow Plasmacytoid Dendritic Cells can Differentiate into Myeloid Dendritic Cells upon Virus Infection.

Zuniga EI, McGavern DB, Pruneda-Paz JL, Teng C, Oldstone MB.

Nat Immunol. 2004 Dec;5(12):1227-34. Epub 2004 Nov 7.

 

 

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