does the ER signal the nucleus?
cells are under stress, they signal the nucleus to do something about
it. Because of our long-standing work on the secretory system we are
particularly interested in the signals that come from unfolded proteins.
Such proteins are present as a result of heat stress or certain chemical
treatments (eg tunicamycin). Unfolded proteins signal the nucleus to
turn on the BiP genes. This is called the Unfolded Protein Response
or UPR. This project was started by Nozomu Koizumi and is now carried
on by Imma Martinez. We have cloned the Ire gene homologues that encode
transmembrane receptor kinases and we are now studying their role in
Characterization of Two Arabidopsis Ire1 Homologs,
Endoplasmic Reticulum-Located Transmembrane Protein Kinases" (pdf)
"Genomic analysis of the unfolded protein response
in Arabidopsis shows its connection to important cellular processes."
Supplemental data for Genomic Analysis
of Arabidopsis UPR