The Yelon Lab

      Division of Biological Sciences

      University of California, San Diego

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Publications

 

Schumacher JA, Bloomekatz J, Garavito-Aguilar ZV, Yelon D. (2013)  tal1 regulates the 
formation of intercellular junctions and the maintenance of identity in the endocardium. 
Developmental  Biology 383: 214-26. 
     

Targoff KL, Colombo S, George V, Schell T, Kim SH, Solnica-Krezel L, Yelon D. (2013) 
Nkx genes are essential for maintenance of ventricular identity. Development 140: 4203-13. 

Miura GI, Yelon D.(2013) Cardiovascular biology: play it again, Gata4. Current Biology 23: R619-21. 
      

Zhang R, Han P, Yang H, Ouyang K, Lee D, Lin YF, Ocorr K, Kang G, Chen J, Stainier DY, Yelon D, Chi NC. (2103) In vivo cardiac reprogramming contributes to zebrafish heart regeneration. Nature 498: 497-501.

Giurumescu CA, Kang S, Planchon TA, Betzig E, Bloomekatz J, Yelon D, Cosman P,
Chisholm AD. (2102) Quantitative semi-automated analysis of morphogenesis with single-cell resolution
in complex embryos. Development 139: 4271-4279.

Yelon D. (2012) Developmental biology: Heart under construction. Nature 484: 459-460.

Lin YF, Swinburne I, Yelon D. (2012) Multiple influences of blood flow on cardiomyocyte hypertrophy in the embryonic zebrafish heart. Developmental Biology 362: 242-253.

Totong R, Schell T, Lescroart F, Ryckebüsch L, Lin YF, Zygmunt T, Herwig L, Krudewig A, Gershoony D, Belting HG, Affolter M, Torres-Vázquez J, Yelon D. (2011) The novel transmembrane protein Tmem2 is essential for coordination of myocardial and endocardial morphogenesis. Development 138: 4199-4205.

Wang J, Panáková D, Kikuchi K, Holdway JE, Gemberling M, Burris JS, Singh SP, Dickson AL, Lin YF, Sabeh MK, Werdich AA, Yelon D, Macrae CA, Poss KD. (2011) The regenerative capacity of zebrafish reverses cardiac failure caused by genetic cardiomyocyte depletion. Development 138: 3421-3430.

Miura GI, Yelon D. (2011) A guide to analysis of cardiac phenotypes in the zebrafish embryo. Methods in Cell Biology 101:168-180.

Waxman JS, Yelon D. (2011) Zebrafish retinoic acid receptors function as context-dependent transcriptional activators. Developmental Biology 352: 128-140.

Peshkovsky C, Totong R, Yelon D. (2011) Dependence of cardiac trabeculation on neuregulin signaling and blood flow in zebrafish. Developmental Dynamics 240: 446-456.

Evans SM, Yelon D, Conlon FL, Kirby ML. (2010) Myocardial lineage development. Circulation Research 107: 1428-1444.

Sogah VM, Serluca FC, Fishman MC, Yelon DL, Macrae CA, Mably JD. (2010) Distinct troponin C isoform requirements in cardiac and skeletal muscle. Developmental Dynamics 239: 3115-3123.

Garavito-Aguilar, Z.V., Riley,H.E., and Yelon, D. (2010) Hand2 ensures an appropriate environment for cardiac fusion by limiting Fibronectin function. Development 137: 3215-3220.

Mandel, E.M., Kaltenbrun, E., Callis, T.E., Zeng, X.X., Marques, S.R., Yelon, D., and Wang, D.Z. (2010) The BMP pathway acts to directly regulate Tbx20 in the developing heart. Development 137: 1919-1929.

Feng, L., Hernandex, R.E., Waxman, J.S., Yelon D., and Moens, CB. (2010) Dhrs3a regulates retinoic acid biosynthesis through a feedback inhibition mechanism. Developmental Biology 338: 1-14.

de Pater, E., L. Clijsters, S. Marques, Y.-F. Lin, Z.V. Garavito-Aguilar, D. Yelon, and J. Bakkers.  (2009)  Distinct phases of cardiomyocyte differentiation regulate growth of the zebrafish heart.  Development 136: 1633-1641. 

Waxman, J.S. and D. Yelon.  (2009) Increased Hox activity mimics the teratogenic effects of excess retinoic acid signaling.  Developmental Dynamics 238: 1207-1213. 

Mich, J.K., H. Blaser, N.A. Thomas, D. Yelon, E. Raz, and J.K. Chen.  (2009)  Germ cell migration in zebrafish is cyclopamine-sensitive but Smoothened-independent. Developmental Biology 328: 342-354. 

Marques, S.R. and D. Yelon.  (2009)  Differential requirement for BMP signaling in atrial and ventricular lineages establishes cardiac chamber proportionality. Developmental Biology, 328: 472-482. 

Linville, A., K. Radtke, J.S. Waxman, D. Yelon, and T.F. Schilling.  (2009)  Combinatorial roles for zebrafish retinoic acid receptors in the hindbrain, limbs and pharyngeal arches.  Developmental Biology 325: 60-70.

Osborne, N., K. Brand-Arzamendi, E.A. Ober, S.W. Jin, H. Verkade, N.G. Holtzman, D. Yelon, and D.Y.R. Stainier.  (2008) The Spinster homologue, Two of Hearts, is required for sphingosine-1-phosphate signaling in zebrafish.  Current Biology 18: 1882-1888. 

Waxman, J.S., B.R. Keegan, R.W. Roberts, K.D. Poss, and D. Yelon.  (2008) Hoxb5b acts downstream of retinoic acid signaling in the forelimb field to restrict heart field potential in zebrafish.  Developmental Cell 15: 923-934. 

de Campos-Baptista M.I., N.G. Holtzman, D. Yelon, and A.F. Schier.  (2008) Nodal signaling promotes the speed and directional movement of cardiomyocytes in zebrafish.  Developmental Dynamics 237: 3624-3633. 

Thomas, N.A., M. Koudijs, F.J.M. van Eeden, A.L. Joyner, and D. Yelon.  (2008)  Hedgehog signaling plays a cell-autonomous role in maximizing cardiac developmental potential.  Development 135: 3789-3799. 

Targoff, K.L., T. Schell, and D. Yelon.  (2008)  Nkx genes regulate heart tube extension and exert differential effects on ventricular and atrial cell number.  Developmental Biology 322: 314-321.

Marques, S.R., Y. Lee, K.D. Poss, and D. Yelon.  (2008)  Reiterative roles for FGF signaling in the establishment of size and proportion of the zebrafish heart.  Developmental Biology 321: 397-406. 

Schoenebeck, J.J., and D. Yelon.  (2007)  Illuminating cardiac development: Advances in imaging add new dimensions to the utility of zebrafish genetics. Seminars in Cell & Developmental Biology 18: 27-35.

Schoenebeck JJ, Keegan BR, Yelon D. (2007). Vessel and blood specification override cardiac potential in anterior mesoderm. Developmental Cell 13: 254-67.

Wendl T, Adzic D, Schoenebeck JJ, Scholpp S, Brand M, Yelon D, Rohr KB. (2007). Early developmental specification of the thyroid gland depends on han-expressing surrounding tissue and on FGF signals. Development. 134: 2871-9.

Holtzman NG, Schoenebeck JJ, Tsai HJ, Yelon D. (2007). Endocardium is necessary for cardiomyocyte movement during heart tube assembly. Development. 134: 2379-86.

Auman HJ, Coleman H, Riley HE, Olale F, Tsai HJ, Yelon D. (2007). Functional modulation of cardiac form through regionally confined cell shape changes. PLoS Biology 5, e53.

Waxman JS, Yelon D. (2007). Comparison of the expression patterns of newly identified zebrafish retinoic acid and retinoid X receptors. Developmental Dynamics 236: 587-95.

Schoenebeck JJ, Yelon D. (2007). Illuminating cardiac development: Advances in imaging add new dimensions to the utility of zebrafish genetics. Seminars in Cell & Developmental Biology 18, 27-35.

Ebert AM, Hume GL, Warren KS, Cook NP, Burns CG, Mohideen MA, Siegal G, Yelon D, Fishman MC, Garrity DM. (2005). Calcium extrusion is critical for cardiac morphogenesis and rhythm in embryonic zebrafish hearts. Proceedings of the National Academy of Sciences USA 102: 17705-10.

Trinh, L.A., Yelon, D., and Stainier, D.Y. (2005). Hand2 regulates epithelial formation during myocardial diferentiation. Current Biology 15: 441-446.

Keegan, B.R., Feldman, J.L., Begemann, G., Ingham, P.W., and Yelon, D. (2005). Retinoic acid signaling restricts the cardiac progenitor pool. Science 307: 247-249.

O'Brien, E.K., d'Alencon, C., Bonde, G., Li, W., Schoenebeck, J., Allende, M.L., Gelb, B.D., Yelon, D., Eisen, J.S., and Cornell, R.A. (2004). Transcription factor Ap-2alpha is necessary for development of embryonic melanophores, autonomic neurons and pharyngeal skeleton in zebrafish. Developmental Biology 265: 246-261.

Keegan, B.R., Meyer, D., and Yelon, D. (2004). Organization of cardiac chamber progenitors in the zebrafish blastula. Development 131: 3081-3091.

Glickman, N.S., and Yelon, D. (2004). Coordinating morphogenesis: epithelial integrity during heart tube assembly. Developmental Cell 6: 311-312.

Auman, H.J., and Yelon, D. (2004). Vertebrate organogenesis: getting the heart into shape. Current Biology 14: R152-153.

Miller, C.T., Yelon, D., Stainier, D.Y., and Kimmel, C.B. (2003). Two endothelin 1 effectors, hand2 and bapx1, pattern ventral pharyngeal cartilage and the jaw joint. Development 130: 1353-1365.

Berdougo, E., Coleman, H., Lee, D.H., Stainier, D.Y., and Yelon, D. (2003). Mutation of weak atrium/atrial myosin heavy chain disrupts atrial function and influences ventricular morphogenesis in zebrafish. Development 130: 6121-6129.

Yelon, D., Weinstein, B.M., and Fishman, M.C. (2002). Cardiovascular system. Results and Problems in Cell Differentiation 40: 298-321.

Yelon, D., and Stainier, D.Y. (2002). Pattern formation: swimming in retinoic acid. Current Biol 12: R707-709.

Yelon, D., Feldman, J.L., and Keegan, B.R. (2002). Genetic regulation of cardiac patterning in zebrafish. Cold Spring Harbor Symposia on Quantitative Biology 67: 19-25.

Keegan, B.R., Feldman, J.L., Lee, D.H., Koos, D.S., Ho, R.K., Stainier, D.Y., and Yelon, D. (2002). The elongation factors Pandora/Spt6 and Foggy/Spt5 promote transcription in the zebrafish embryo. Development 129: 1623-1632.

Glickman, N.S., and Yelon, D. (2002). Cardiac development in zebrafish: coordination of form and function. Seminars in Cell &Developmental Biology 13: 507-513.

Yelon, D. (2001). Cardiac patterning and morphogenesis in zebrafish. Developmental Dynamics 222: 552-563.

Kikuchi, Y., Agathon, A., Alexander, J., Thisse, C., Waldron, S., Yelon, D., Thisse, B., and Stainier, D.Y. (2001). casanova encodes a novel Sox-related protein necessary and sufficient for early endoderm formation in zebrafish. Genes & Development 15: 1493-1505.

Yelon, D., Ticho, B., Halpern, M.E., Ruvinsky, I., Ho, R.K., Silver, L.M., and Stainier, D.Y. (2000). The bHLH transcription factor hand2 plays parallel roles in zebrafish heart and pectoral fin development. Development 127: 2573-2582.

Kikuchi, Y., Trinh, L.A., Reiter, J.F., Alexander, J., Yelon, D., and Stainier, D.Y. (2000). The zebrafish bonnie and clyde gene encodes a Mix family homeodomain protein that regulates the generation of endodermal precursors. Genes & Development 14: 1279-1289.

Griffin, K.J., Stoller, J., Gibson, M., Chen, S., Yelon, D., Stainier, D.Y., and Kimelman, D. (2000). A conserved role for H15-related T-box transcription factors in zebrafish and Drosophila heart formation. Developmental Biology 218: 235-247.

Yelon, D., and Stainier, D.Y. (1999). Patterning during organogenesis: genetic analysis of cardiac chamber formation. Seminars in Cell & Developmental Biology 10: 93-98.

Yelon, D., Horne, S.A., and Stainier, D.Y. (1999). Restricted expression of cardiac myosin genes reveals regulated aspects of heart tube assembly in zebrafish. Developmental Biology 214: 23-37.

Reiter, J.F., Alexander, J., Rodaway, A., Yelon, D., Patient, R., Holder, N., and Stainier, D.Y. (1999). Gata5 is required for the development of the heart and endoderm in zebrafish. Genes & Development 13: 2983-2995.


Alexander, J., Stainier, D.Y., and Yelon, D. (1998). Screening mosaic F1 females for mutations affecting zebrafish heart induction and patterning. Developmental Genetics 22: 288-299.