The Yelon Lab

      Division of Biological Sciences

      University of California, San Diego

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Schumacher JA, Bloomekatz J, Garavito-Aguilar ZV, Yelon D. (2013)  tal1 regulates the 
formation of intercellular junctions and the maintenance of identity in the endocardium. 
Developmental  Biology 383: 214-26. PubMed Search
Targoff KL, Colombo S, George V, Schell T, Kim SH, Solnica-Krezel L, Yelon D. (2013) 
Nkx genes are essential for maintenance of ventricular identity. Development 140: 4203-13. PubMed Search
Miura GI, Yelon D.(2013) Cardiovascular biology: play it again, Gata4. Current Biology 23: R619-21. PubMed Search

Zhang R, Han P, Yang H, Ouyang K, Lee D, Lin YF, Ocorr K, Kang G, Chen J, Stainier DY, Yelon D, Chi NC. (2103) In vivo cardiac reprogramming contributes to zebrafish heart regeneration. Nature 498: 497-501. PubMed Search

Giurumescu CA, Kang S, Planchon TA, Betzig E, Bloomekatz J, Yelon D, Cosman P,
Chisholm AD. (2102) Quantitative semi-automated analysis of morphogenesis with single-cell resolution
in complex embryos. Development 139: 4271-4279. PubMed Search

Yelon D. (2012) Developmental biology: Heart under construction. Nature 484: 459-460. PubMed Search

Lin YF, Swinburne I, Yelon D. (2012) Multiple influences of blood flow on cardiomyocyte hypertrophy in the embryonic zebrafish heart. Developmental Biology 362: 242-253. PubMed Search

Totong R, Schell T, Lescroart F, Ryckebüsch L, Lin YF, Zygmunt T, Herwig L, Krudewig A, Gershoony D, Belting HG, Affolter M, Torres-Vázquez J, Yelon D. (2011) The novel transmembrane protein Tmem2 is essential for coordination of myocardial and endocardial morphogenesis. Development 138: 4199-4205. PubMed Search

Wang J, Panáková D, Kikuchi K, Holdway JE, Gemberling M, Burris JS, Singh SP, Dickson AL, Lin YF, Sabeh MK, Werdich AA, Yelon D, Macrae CA, Poss KD. (2011) The regenerative capacity of zebrafish reverses cardiac failure caused by genetic cardiomyocyte depletion. Development 138: 3421-3430. PubMed Search

Miura GI, Yelon D. (2011) A guide to analysis of cardiac phenotypes in the zebrafish embryo. Methods in Cell Biology 101:168-180. PubMed Search

Waxman JS, Yelon D. (2011) Zebrafish retinoic acid receptors function as context-dependent transcriptional activators. Developmental Biology 352: 128-140. PubMed Search

Peshkovsky C, Totong R, Yelon D. (2011) Dependence of cardiac trabeculation on neuregulin signaling and blood flow in zebrafish. Developmental Dynamics 240: 446-456. PubMed Search

Evans SM, Yelon D, Conlon FL, Kirby ML. (2010) Myocardial lineage development. Circulation Research 107: 1428-1444. PubMed Search

Sogah VM, Serluca FC, Fishman MC, Yelon DL, Macrae CA, Mably JD. (2010) Distinct troponin C isoform requirements in cardiac and skeletal muscle. Developmental Dynamics 239: 3115-3123. PubMed Search

Garavito-Aguilar, Z.V., Riley,H.E., and Yelon, D. (2010) Hand2 ensures an appropriate environment for cardiac fusion by limiting Fibronectin function. Development 137: 3215-3220. PubMed Search

Mandel, E.M., Kaltenbrun, E., Callis, T.E., Zeng, X.X., Marques, S.R., Yelon, D., and Wang, D.Z. (2010) The BMP pathway acts to directly regulate Tbx20 in the developing heart. Development 137: 1919-1929. PubMed Search

Feng, L., Hernandex, R.E., Waxman, J.S., Yelon D., and Moens, CB. (2010) Dhrs3a regulates retinoic acid biosynthesis through a feedback inhibition mechanism. Developmental Biology 338: 1-14. PubMed Search

de Pater, E., L. Clijsters, S. Marques, Y.-F. Lin, Z.V. Garavito-Aguilar, D. Yelon, and J. Bakkers.  (2009)  Distinct phases of cardiomyocyte differentiation regulate growth of the zebrafish heart.  Development 136: 1633-1641.  PubMed Search

Waxman, J.S. and D. Yelon.  (2009) Increased Hox activity mimics the teratogenic effects of excess retinoic acid signaling.  Developmental Dynamics 238: 1207-1213.  PubMed Search

Mich, J.K., H. Blaser, N.A. Thomas, D. Yelon, E. Raz, and J.K. Chen.  (2009)  Germ cell migration in zebrafish is cyclopamine-sensitive but Smoothened-independent. Developmental Biology 328: 342-354.  PubMed Search

Marques, S.R. and D. Yelon.  (2009)  Differential requirement for BMP signaling in atrial and ventricular lineages establishes cardiac chamber proportionality. Developmental Biology, 328: 472-482.  PubMed Search

Linville, A., K. Radtke, J.S. Waxman, D. Yelon, and T.F. Schilling.  (2009)  Combinatorial roles for zebrafish retinoic acid receptors in the hindbrain, limbs and pharyngeal arches.  Developmental Biology 325: 60-70. PubMed Search

Osborne, N., K. Brand-Arzamendi, E.A. Ober, S.W. Jin, H. Verkade, N.G. Holtzman, D. Yelon, and D.Y.R. Stainier.  (2008) The Spinster homologue, Two of Hearts, is required for sphingosine-1-phosphate signaling in zebrafish.  Current Biology 18: 1882-1888.  PubMed Search

Waxman, J.S., B.R. Keegan, R.W. Roberts, K.D. Poss, and D. Yelon.  (2008) Hoxb5b acts downstream of retinoic acid signaling in the forelimb field to restrict heart field potential in zebrafish.  Developmental Cell 15: 923-934.  PubMed Search

de Campos-Baptista M.I., N.G. Holtzman, D. Yelon, and A.F. Schier.  (2008) Nodal signaling promotes the speed and directional movement of cardiomyocytes in zebrafish.  Developmental Dynamics 237: 3624-3633.  PubMed Search

Thomas, N.A., M. Koudijs, F.J.M. van Eeden, A.L. Joyner, and D. Yelon.  (2008)  Hedgehog signaling plays a cell-autonomous role in maximizing cardiac developmental potential.  Development 135: 3789-3799.  PubMed Search

Targoff, K.L., T. Schell, and D. Yelon.  (2008)  Nkx genes regulate heart tube extension and exert differential effects on ventricular and atrial cell number.  Developmental Biology 322: 314-321. PubMed Search

Marques, S.R., Y. Lee, K.D. Poss, and D. Yelon.  (2008)  Reiterative roles for FGF signaling in the establishment of size and proportion of the zebrafish heart.  Developmental Biology 321: 397-406.  PubMed Search

Schoenebeck, J.J., and D. Yelon.  (2007)  Illuminating cardiac development: Advances in imaging add new dimensions to the utility of zebrafish genetics. Seminars in Cell & Developmental Biology 18: 27-35. PubMed Search

Schoenebeck JJ, Keegan BR, Yelon D. (2007). Vessel and blood specification override cardiac potential in anterior mesoderm. Developmental Cell 13: 254-67. PubMed Search

Wendl T, Adzic D, Schoenebeck JJ, Scholpp S, Brand M, Yelon D, Rohr KB. (2007). Early developmental specification of the thyroid gland depends on han-expressing surrounding tissue and on FGF signals. Development. 134: 2871-9. PubMed Search

Holtzman NG, Schoenebeck JJ, Tsai HJ, Yelon D. (2007). Endocardium is necessary for cardiomyocyte movement during heart tube assembly. Development. 134: 2379-86. PubMed Search

Auman HJ, Coleman H, Riley HE, Olale F, Tsai HJ, Yelon D. (2007). Functional modulation of cardiac form through regionally confined cell shape changes. PLoS Biology 5, e53. PubMed Search

Waxman JS, Yelon D. (2007). Comparison of the expression patterns of newly identified zebrafish retinoic acid and retinoid X receptors. Developmental Dynamics 236: 587-95.PubMed Search

Schoenebeck JJ, Yelon D. (2007). Illuminating cardiac development: Advances in imaging add new dimensions to the utility of zebrafish genetics. Seminars in Cell & Developmental Biology 18, 27-35.PubMed Search

Ebert AM, Hume GL, Warren KS, Cook NP, Burns CG, Mohideen MA, Siegal G, Yelon D, Fishman MC, Garrity DM. (2005). Calcium extrusion is critical for cardiac morphogenesis and rhythm in embryonic zebrafish hearts. Proceedings of the National Academy of Sciences USA 102: 17705-10.PubMed Search

Trinh, L.A., Yelon, D., and Stainier, D.Y. (2005). Hand2 regulates epithelial formation during myocardial diferentiation. Current Biology 15: 441-446.PubMed Search

Keegan, B.R., Feldman, J.L., Begemann, G., Ingham, P.W., and Yelon, D. (2005). Retinoic acid signaling restricts the cardiac progenitor pool. Science 307: 247-249. PubMed Search

O'Brien, E.K., d'Alencon, C., Bonde, G., Li, W., Schoenebeck, J., Allende, M.L., Gelb, B.D., Yelon, D., Eisen, J.S., and Cornell, R.A. (2004). Transcription factor Ap-2alpha is necessary for development of embryonic melanophores, autonomic neurons and pharyngeal skeleton in zebrafish. Developmental Biology 265: 246-261.PubMed Search

Keegan, B.R., Meyer, D., and Yelon, D. (2004). Organization of cardiac chamber progenitors in the zebrafish blastula. Development 131: 3081-3091.

Glickman, N.S., and Yelon, D. (2004). Coordinating morphogenesis: epithelial integrity during heart tube assembly. Developmental Cell 6: 311-312.PubMed Search

Auman, H.J., and Yelon, D. (2004). Vertebrate organogenesis: getting the heart into shape. Current Biology 14: R152-153.PubMed Search

Miller, C.T., Yelon, D., Stainier, D.Y., and Kimmel, C.B. (2003). Two endothelin 1 effectors, hand2 and bapx1, pattern ventral pharyngeal cartilage and the jaw joint. Development 130: 1353-1365.PubMed Search

Berdougo, E., Coleman, H., Lee, D.H., Stainier, D.Y., and Yelon, D. (2003). Mutation of weak atrium/atrial myosin heavy chain disrupts atrial function and influences ventricular morphogenesis in zebrafish. Development 130: 6121-6129.PubMed Search

Yelon, D., Weinstein, B.M., and Fishman, M.C. (2002). Cardiovascular system. Results and Problems in Cell Differentiation 40: 298-321.PubMed Search

Yelon, D., and Stainier, D.Y. (2002). Pattern formation: swimming in retinoic acid. Current Biol 12: R707-709.PubMed Search

Yelon, D., Feldman, J.L., and Keegan, B.R. (2002). Genetic regulation of cardiac patterning in zebrafish. Cold Spring Harbor Symposia on Quantitative Biology 67: 19-25.PubMed Search

Keegan, B.R., Feldman, J.L., Lee, D.H., Koos, D.S., Ho, R.K., Stainier, D.Y., and Yelon, D. (2002). The elongation factors Pandora/Spt6 and Foggy/Spt5 promote transcription in the zebrafish embryo. Development 129: 1623-1632.PubMed Search

Glickman, N.S., and Yelon, D. (2002). Cardiac development in zebrafish: coordination of form and function. Seminars in Cell &Developmental Biology 13: 507-513.PubMed Search

Yelon, D. (2001). Cardiac patterning and morphogenesis in zebrafish. Developmental Dynamics 222: 552-563.PubMed Search

Kikuchi, Y., Agathon, A., Alexander, J., Thisse, C., Waldron, S., Yelon, D., Thisse, B., and Stainier, D.Y. (2001). casanova encodes a novel Sox-related protein necessary and sufficient for early endoderm formation in zebrafish. Genes & Development 15: 1493-1505.PubMed Search

Yelon, D., Ticho, B., Halpern, M.E., Ruvinsky, I., Ho, R.K., Silver, L.M., and Stainier, D.Y. (2000). The bHLH transcription factor hand2 plays parallel roles in zebrafish heart and pectoral fin development. Development 127: 2573-2582.PubMed Search

Kikuchi, Y., Trinh, L.A., Reiter, J.F., Alexander, J., Yelon, D., and Stainier, D.Y. (2000). The zebrafish bonnie and clyde gene encodes a Mix family homeodomain protein that regulates the generation of endodermal precursors. Genes & Development 14: 1279-1289.PubMed Search

Griffin, K.J., Stoller, J., Gibson, M., Chen, S., Yelon, D., Stainier, D.Y., and Kimelman, D. (2000). A conserved role for H15-related T-box transcription factors in zebrafish and Drosophila heart formation. Developmental Biology 218: 235-247.PubMed Search

Yelon, D., and Stainier, D.Y. (1999). Patterning during organogenesis: genetic analysis of cardiac chamber formation. Seminars in Cell & Developmental Biology 10: 93-98.PubMed Search

Yelon, D., Horne, S.A., and Stainier, D.Y. (1999). Restricted expression of cardiac myosin genes reveals regulated aspects of heart tube assembly in zebrafish. Developmental Biology 214: 23-37.PubMed Search

Reiter, J.F., Alexander, J., Rodaway, A., Yelon, D., Patient, R., Holder, N., and Stainier, D.Y. (1999). Gata5 is required for the development of the heart and endoderm in zebrafish. Genes & Development 13: 2983-2995.
PubMed Search

Alexander, J., Stainier, D.Y., and Yelon, D. (1998). Screening mosaic F1 females for mutations affecting zebrafish heart induction and patterning. Developmental Genetics 22: 288-299.PubMed Search


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