REFERENCES

Agne, B., N.M. Meindl, K. Niederhoff, H. Einwachter, P. Rehling, A. Sickmann, H.E. Meyer, W. Girzalsky, and W.H. Kunau. 2003. Pex8p: an intraperoxisomal organizer of the peroxisomal import machinery. Mol Cell. 11:635-46.

Albertini, M., P. Rehling, R. Erdmann, W. Girzalsky, J.A. Kiel, M. Veenhuis, and W.H. Kunau. 1997. Pex14p, a peroxisomal membrane protein binding both receptors of the two PTS-dependent import pathways. Cell. 89:83-92.

Azevedo, J.E., J. Costa-Rodrigues, C.P. Guimaraes, M.E. Oliveira, and C. Sa-Miranda. 2004. Protein translocation across the peroxisomal membrane. Cell Biochem Biophys. 41:451-68.

Banerjee, S.K., P.S. Kessler, T. Saveria, and M. Parsons. 2005. Identification of trypanosomatid PEX19: functional characterization reveals impact on cell growth and glycosome size and number. Mol Biochem Parasitol. 142:47-55.

Bottger, G., P. Barnett, A.T. Klein, A. Kragt, H.F. Tabak, and B. Distel. 2000. Saccharomyces cerevisiae PTS1 receptor Pex5p interacts with the SH3 domain of the peroxisomal membrane protein Pex13p in an unconventional, non-PXXP-related manner. Mol Biol Cell. 11:3963-76.

Braverman, N., G. Steel, C. Obie, A. Moser, H. Moser, S.J. Gould, and D. Valle. 1997. Human PEX7 encodes the peroxisomal PTS2 receptor and is responsible for rhizomelic chondrodysplasia punctata. Nat Genet. 15:369-76.

Collins, C.S., J.E. Kalish, J.C. Morrell, J.M. McCaffery, and S.J. Gould. 2000. The peroxisome biogenesis factors pex4p, pex22p, pex1p, and pex6p act in the terminal steps of peroxisomal matrix protein import. Mol Cell Biol. 20:7516-26.

Costa-Rodrigues, J., A.F. Carvalho, A.M. Gouveia, M. Fransen, C. Sa-Miranda, and J.E. Azevedo. 2004. The N terminus of the peroxisomal cycling receptor, Pex5p, is required for redirecting the peroxisome-associated peroxin back to the cytosol. J Biol Chem. 279:46573-9.

Dammai, V., and S. Subramani. 2001. The human peroxisomal targeting signal receptor, Pex5p, is translocated into the peroxisomal matrix and recycled to the cytosol. Cell. 105:187-96.

Dodt, G., N. Braverman, C. Wong, A. Moser, H.W. Moser, P. Watkins, D. Valle, and S.J. Gould. 1995. Mutations in the PTS1 receptor gene, PXR1, define complementation group 2 of the peroxisome biogenesis disorders. Nat Genet. 9:115-25.

Dodt, G., and S.J. Gould. 1996. Multiple PEX genes are required for proper subcellular distribution and stability of Pex5p, the PTS1 receptor: evidence that PTS1 protein import is mediated by a cycling receptor. J Cell Biol. 135:1763-74.

Dodt, G., D. Warren, E. Becker, P. Rehling, and S.J. Gould. 2001. Domain Mapping of Human PEX5 Reveals Functional and Structural Similarities to Saccharomyces cerevisiae Pex18p and Pex21p. J. Biol. Chem. 276:41769-41781.

Einwächter, H., S. Sowinski, W.H. Kunau, and W. Schliebs. 2001. Yarrowia lipolytica Pex20p, Saccharomyces cerevisiae Pex18p/Pex21p and mammalian Pex5pL fulfil a common function in the early steps of the peroxisomal PTS2 import pathway. EMBO Rep. 2:1035-1039.

Elgersma, Y., M. Elgersma-Hooisma, T. Wenzel, J.M. McCaffery, M.G. Farquhar, and S. Subramani. 1998. A mobile PTS2 receptor for peroxisomal protein import in Pichia pastoris. J Cell Biol. 140:807-20.
Erdmann, R., and W. Schliebs. 2005. Peroxisomal matrix protein import: the transient pore model. Nat Rev Mol Cell Biol. 6:738-42.

Fang, Y., J.C. Morrell, J.M. Jones, and S.J. Gould. 2004. PEX3 functions as a PEX19 docking factor in the import of class I peroxisomal membrane proteins. J Cell Biol. 164:863-75.

Girzalsky, W., P. Rehling, K. Stein, J. Kipper, L. Blank, W.H. Kunau, and R. Erdmann. 1999. Involvement of Pex13p in Pex14p localization and peroxisomal targeting signal 2-dependent protein import into peroxisomes. J Cell Biol. 144:1151-62.

Gouveia, A.M., C.P. Guimaraes, M.E. Oliveira, C. Reguenga, C. Sa-Miranda, and J.E. Azevedo. 2003a. Characterization of the peroxisomal cycling receptor, Pex5p, using a cell-free in vitro import system. J Biol Chem. 278:226-30.

Gouveia, A.M., C.P. Guimaraes, M.E. Oliveira, C. Sa-Miranda, and J.E. Azevedo. 2003b. Insertion of Pex5p into the peroxisomal membrane is cargo protein-dependent. J Biol Chem. 278:4389-4392.
Gouveia, A.M., C. Reguenga, M.E. Oliveira, C. Sa-Miranda, and J.E. Azevedo. 2000. Characterization of peroxisomal Pex5p from rat liver. Pex5p in the Pex5p-Pex14p membrane complex is a transmembrane protein. J Biol Chem. 275:32444-32451.

Hayashi, M., M. Yagi, K. Nito, T. Kamada, and M. Nishimura. 2005. Differential contribution of two peroxisomal protein receptors to the maintenance of peroxisomal functions in Arabidopsis. J Biol Chem. 280:14829-35.
Hazra, P.P., I. Suriapranata, W.B. Snyder, and S. Subramani. 2002. Peroxisome remnants in pex3Δ cells and the requirement of Pex3p for interactions between the peroxisomal docking and translocation subcomplexes. Traffic. 3:560-74.

Heiland, I., and R. Erdmann. 2005. Biogenesis of peroxisomes. Topogenesis of the peroxisomal membrane and matrix proteins. Febs J. 272:2362-72.
Hettema, E.H., W. Girzalsky, M. van Den Berg, R. Erdmann, and B. Distel. 2000. Saccharomyces cerevisiae pex3p and pex19p are required for proper localization and stability of peroxisomal membrane proteins. Embo J. 19:223-33.

Hoepfner, D., D. Schildknegt, I. Braakman, P. Philippsen, and H.F. Tabak. 2005. Contribution of the endoplasmic reticulum to peroxisome formation. Cell. 122:85-95.
Jones, J.M., J.C. Morrell, and S.J. Gould. 2004. PEX19 is a predominantly cytosolic chaperone and import receptor for class 1 peroxisomal membrane proteins. J Cell Biol. 164:57-67.

Kerssen, D., E. Hambruch, W. Klaas, H.W. Platta, B. de Kruijff, R. Erdmann, W.H. Kunau, and W. Schliebs. 2006. Membrane association of the cycling peroxisome import receptor Pex5p. J Biol Chem.

Kiel, J.A., K. Emmrich, H.E. Meyer, and W.H. Kunau. 2005a. Ubiquitination of the peroxisomal targeting signal type 1 receptor, Pex5p, suggests the presence of a quality control mechanism during peroxisomal matrix protein import. J Biol Chem. 280:1921-30.

Kiel, J.A., M. Otzen, M. Veenhuis, and I.J. van der Klei. 2005b. Obstruction of polyubiquitination affects PTS1 peroxisomal matrix protein import. Biochim Biophys Acta. 1745:176-86.

Koller, A., W.B. Snyder, K.N. Faber, T.J. Wenzel, L. Rangell, G.A. Keller, and S. Subramani. 1999. Pex22p of Pichia pastoris, essential for peroxisomal matrix protein import, anchors the ubiquitin-conjugating enzyme, Pex4p, on the peroxisomal membrane. J Cell Biol. 146:99-112.

Kragt, A., T. Voorn-Brouwer, M. van den Berg, and B. Distel. 2005. The Saccharomyces cerevisiae peroxisomal import receptor Pex5p is monoubiquitinated in wild type cells. J Biol Chem. 280:7867-74.

Kunau, W.H. 2001. Peroxisomes: the extended shuttle to the peroxisome matrix. Curr Biol. 11:R659-62.
Lambkin, G.R., and R.A. Rachubinski. 2001. Yarrowia lipolytica cells mutant for the peroxisomal peroxin Pex19p contain structures resembling wild-type peroxisomes. Mol Biol Cell. 12:3353-64.

Lazarow, P.B. 2003. Peroxisome biogenesis: advances and conundrums. Curr Opin Cell Biol. 15:489-97.
Leon, S., L. Zhang, W.H. McDonald, J. Yates, 3rd, J.M. Cregg, and S. Subramani. 2006. Dynamics of the peroxisomal import cycle of PpPex20p: ubiquitin-dependent localization and regulation. J Cell Biol. 172:67-78.

Marzioch, M., R. Erdmann, M. Veenhuis, and W.H. Kunau. 1994. PAS7 encodes a novel yeast member of the WD-40 protein family essential for import of 3-oxoacyl-CoA thiolase, a PTS2-containing protein, into peroxisomes. Embo J. 13:4908-18.

Matsumura, T., H. Otera, and Y. Fujiki. 2000. Disruption of the interaction of the longer isoform of Pex5p, Pex5pL, with Pex7p abolishes peroxisome targeting signal type 2 protein import in mammals. Study with a novel Pex5-impaired Chinese hamster ovary cell mutant. J Biol Chem. 275:21715-21.

McCollum, D., E. Monosov, and S. Subramani. 1993. The pas8 mutant of Pichia pastoris exhibits the peroxisomal protein import deficiencies of Zellweger syndrome cells--the PAS8 protein binds to the COOH-terminal tripeptide peroxisomal targeting signal, and is a member of the TPR protein family. J Cell Biol. 121:761-74.

Miyata, N., and Y. Fujiki. 2005. Shuttling mechanism of peroxisome targeting signal type 1 receptor Pex5: ATP-independent import and ATP-dependent export. Mol Cell Biol. 25:10822-32.

Mukai, S., K. Ghaedi, and Y. Fujiki. 2002. Intracellular localization, function, and dysfunction of the peroxisome- targeting signal type 2 receptor, Pex7p, in mammalian cells. J Biol Chem. 277:9548-9561.

Nair, D.M., P.E. Purdue, and P.B. Lazarow. 2004. Pex7p translocates in and out of peroxisomes in Saccharomyces cerevisiae. J Cell Biol. 167:599-604.

Niederhoff, K., N.M. Meindl-Beinker, D. Kerssen, U. Perband, A. Schafer, W. Schliebs, and W.H. Kunau. 2005. Yeast Pex14p possesses two functionally distinct Pex5p and one Pex7p binding sites. J Biol Chem. 280:35571-8.
Otera, H., T. Harano, M. Honsho, K. Ghaedi, S. Mukai, A. Tanaka, A. Kawai, N. Shimizu, and Y. Fujiki. 2000. The mammalian peroxin Pex5pL, the longer isoform of the mobile peroxisome targeting signal (PTS) type 1 transporter, translocates the Pex7p.PTS2 protein complex into peroxisomes via its initial docking site, Pex14p. J Biol Chem. 275:21703-14.

Otzen, M., U. Perband, D. Wang, R.J. Baerends, W.H. Kunau, M. Veenhuis, and I.J. Van der Klei. 2004. Hansenula polymorpha Pex19p is essential for the formation of functional peroxisomal membranes. J Biol Chem. 279:19181-90.

Otzen, M., D. Wang, M.G. Lunenborg, and I.J. van der Klei. 2005. Hansenula polymorpha Pex20p is an oligomer that binds the peroxisomal targeting signal 2 (PTS2). J Cell Sci. 118:3409-18.
Platta, H.W., W. Girzalsky, and R. Erdmann. 2004. Ubiquitination of the peroxisomal import receptor Pex5p. Biochem J. 384:37-45.

Platta, H.W., S. Grunau, K. Rosenkranz, W. Girzalsky, and R. Erdmann. 2005. Functional role of the AAA peroxins in dislocation of the cycling PTS1 receptor back to the cytosol. Nat Cell Biol. 7:817-22.
Pool, M.R. 2005. Signal recognition particles in chloroplasts, bacteria, yeast and mammals (review). Mol Membr Biol. 22:3-15.

Purdue, P.E., and P.B. Lazarow. 2001. Pex18p is constitutively degraded during peroxisome biogenesis. J Biol Chem. 276:47684-47689.

Purdue, P.E., X. Yang, and P.B. Lazarow. 1998. Pex18p and Pex21p, a novel pair of related peroxins essential for peroxisomal targeting by the PTS2 pathway. J Cell Biol. 143:1859-1869.

Rachubinski, R.A., and S. Subramani. 1995. How proteins penetrate peroxisomes. Cell. 83:525-8.

Rehling, P., M. Marzioch, F. Niesen, E. Wittke, M. Veenhuis, and W.H. Kunau. 1996. The import receptor for the peroxisomal targeting signal 2 (PTS2) in Saccharomyces cerevisiae is encoded by the PAS7 gene. Embo J. 15:2901-13.

Romisch, K. 2005. Endoplasmic reticulum-associated degradation. Annu Rev Cell Dev Biol. 21:435-56.
Sacksteder, K.A., J.M. Jones, S.T. South, X. Li, Y. Liu, and S.J. Gould. 2000. PEX19 binds multiple peroxisomal membrane proteins, is predominantly cytoplasmic, and is required for peroxisome membrane synthesis. J Cell Biol. 148:931-44.

Schäfer, A., D. Kerssen, M. Veenhuis, W.H. Kunau, and W. Schliebs. 2004. Functional Similarity between the Peroxisomal PTS2 Receptor Binding Protein Pex18p and the N-Terminal Half of the PTS1 Receptor Pex5p. Mol Cell Biol. 24:8895-8906.

Smith, J.J., and R.A. Rachubinski. 2001. A role for the peroxin Pex8p in Pex20p-dependent thiolase import into peroxisomes of the yeast Yarrowia lipolytica. J Biol Chem. 276:1618-25.

Snyder, W.B., A. Koller, A.J. Choy, and S. Subramani. 2000. The peroxin Pex19p interacts with multiple, integral membrane proteins at the peroxisomal membrane. J Cell Biol. 149:1171-8.
Stein, K., A. Schell-Steven, R. Erdmann, and H. Rottensteiner. 2002. Interactions of Pex7p and Pex18p/Pex21p with the peroxisomal docking machinery: implications for the first steps in PTS2 protein import. Mol Cell Biol. 22:6056-69.

Terlecky, S.R., W.M. Nuttley, D. McCollum, E. Sock, and S. Subramani. 1995. The Pichia pastoris peroxisomal protein PAS8p is the receptor for the C-terminal tripeptide peroxisomal targeting signal. Embo J. 14:3627-34.
Titorenko, V.I., J.J. Smith, R.K. Szilard, and R.A. Rachubinski. 1998. Pex20p of the yeast Yarrowia lipolytica is required for the oligomerization of thiolase in the cytosol and for its targeting to the peroxisome. J Cell Biol. 142:403-420.

van der Klei, I.J., R.E. Hilbrands, J.A. Kiel, S.W. Rasmussen, J.M. Cregg, and M. Veenhuis. 1998. The ubiquitin-conjugating enzyme Pex4p of Hansenula polymorpha is required for efficient functioning of the PTS1 import machinery. EMBO J. 17:3608-3618.

Walter, P., and G. Blobel. 1981. Translocation of proteins across the endoplasmic reticulum. II. Signal recognition protein (SRP) mediates the selective binding to microsomal membranes of in-vitro-assembled polysomes synthesizing secretory protein. J Cell Biol. 91:551-6.

Wang, D., N.V. Visser, M. Veenhuis, and I.J. van der Klei. 2003. Physical interactions of the peroxisomal targeting signal 1 receptor pex5p, studied by fluorescence correlation spectroscopy. J Biol Chem. 278:43340-5.
Waterham, H.R., V.I. Titorenko, P. Haima, J.M. Cregg, W. Harder, and M. Veenhuis. 1994. The Hansenula polymorpha PER1 gene is essential for peroxisome biogenesis and encodes a peroxisomal matrix protein with both carboxy- and amino-terminal targeting signals. J Cell Biol. 127:737-49.

Wiemer, E.A., W.M. Nuttley, B.L. Bertolaet, X. Li, U. Francke, M.J. Wheelock, U.K. Anne, K.R. Johnson, and S. Subramani. 1995. Human peroxisomal targeting signal-1 receptor restores peroxisomal protein import in cells from patients with fatal peroxisomal disorders. J Cell Biol. 130:51-65.

Woodward, A.W., and B. Bartel. 2005. The Arabidopsis Peroxisomal Targeting Signal Type 2 Receptor PEX7 Is Necessary for Peroxisome Function and Dependent on PEX5. Mol. Biol. Cell. 16:573-583.

Yahraus, T., N. Braverman, G. Dodt, J.E. Kalish, J.C. Morrell, H.W. Moser, D. Valle, and S.J. Gould. 1996. The peroxisome biogenesis disorder group 4 gene, PXAAA1, encodes a cytoplasmic ATPase required for stability of the PTS1 receptor. EMBO J. 15:2914-23.

Zhang, J.W., X. Cai, and P.B. Lazarow. 1996. Peb1p (Pas7p) is an intra-peroxisomal receptor for the N-terminal, type 2, peroxisomal targeting signal of thiolase. Ann N Y Acad Sci. 804:654-5.

Zhang, J.W., and P.B. Lazarow. 1995. PEB1 (PAS7) in Saccharomyces cerevisiae encodes a hydrophilic, intra-peroxisomal protein that is a member of the WD repeat family and is essential for the import of thiolase into peroxisomes. J Cell Biol. 129:65-80.

Zhang, J.W., and P.B. Lazarow. 1996. Peb1p (Pas7p) is an intraperoxisomal receptor for the NH2-terminal, type 2, peroxisomal targeting sequence of thiolase: Peb1p itself is targeted to peroxisomes by an NH2-terminal peptide. J Cell Biol. 132:325-34.

Zhang, L., S. Leon, and S. Subramani. 2006. Two independent pathways traffic the intraperoxisomal peroxin PpPex8p into peroxisomes: mechanism and evolutionary implications. Mol Biol Cell. 17:690-9.