The Subramani Lab, University of California, San Diego, Division of Biological Sciences Publications from 2006-1987 See what our current research projects right now
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Publications 2006-2000
Publications 1995-1975

Wiemer, E. A. C., Terlecky, S. R., Nuttley, W. M., Subramani, S. Characterization of the yeast and human receptors for the carboxy-terminal, tripeptide peroxisomal targeting signal.  Cold Spring Harbor Symp. Quant. Biol. Vol LX, 637-648 (1995).

Rachubinski, R., Subramani, S.  How proteins penetrate peroxisomes. Cell,  83: 525-528 (1995).
Kanter-Smoler, G., Knudsen, K. E., Jimenez, G., Sunnerhagen, P., Subramani, S. Separation of phenotypes in mutant alleles of the Schizosaccharomyces pombe  cell-cycle checkpoint gene, rad1+, Mol. Biol. Cell, 6: 1793-1805 (1995).

Terlecky, S.R., Nuttley, W. M.,  McCollum, D., Sock, E., Subramani, S.  The Pichia pastoris peroxisomal protein, PAS8p, is the receptor  for the carboxy-terminal, tripeptide peroxisomal targeting signal. EMBO J. 14: 3627-3634 (1995).

Wiemer, E. A. C., Nuttley, W. M., Bertolaet, B. L., Li, X., Francke, U., Wheelock, M. J., Anne, U. K., Johnson, K. R., Subramani, S. The human PTS1 receptor restores peroxisomal protein import in cells from patients with fatal peroxisomal disorders. J. Cell Biol. 130: 51-65  (1995).

Walton, P. A., Hill, P. E., Subramani, S. Import of stably-folded proteins into peroxisomes. Mol. Biol. Cell, 6: 675-683  (1995).

Birkenbihl, R. P., Subramani, S. The rad21 gene product of Schizosaccharomyces pombe is a cell-cycle-regulated phosphoprotein essential for chromosome segregation and nuclear organization during mitosis. J. Biol. Chem. 270: 7703-7711  (1995).

Wiemer, E. A. C., Subramani, S. Protein import deficiencies in human peroxisomal disorders. Mol. Genet. Med. 4:119-152 (1994).

Heyman, J. A., Monosov, E., Subramani, S. Role of the PAS1 gene of Pichia pastoris in peroxisome biogenesis. J. Cell Biol. 127:1259-1273 (1994).

Walton, P. A., Wendland, M., Subramani, S., Rachubinski, R. A., Welch, W. J. Involvement of 70-kD heat-shock proteins in peroxisomal import. J. Cell Biol. 125:1037-1046 (1994).

Alvares, K., Fan, C. V., Dadras, S., Yeldandi, A. V., Rachubinski, R. A., Capone, J. P., Subramani, S., Iannaccone, P. M., Rao, M. S., Reddy, J. K. An upstream region of the enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase gene directs luciferase expression in liver in response to peroxisome proliferators in transgenic mice. Cancer Res. 54: 2303-2306 (1994).

Ferguson, A. T., Subramani, S. Complex functional interactions at the early enhancer of the PQ strain of  BK virus. J. Virol. 68: 4274-4286 (1994).

Long, K. E., Sunnerhagen, P., Subramani, S. The Schizosaccharomyces pombe rad1 gene consists of 3 exons and the cDNA sequence is partially homologous to the Ustilago maydis REC1 cDNA. Gene, 148:155-159 (1994).

Glover, J. R., Andrews, D. W., Subramani, S., Rachubinski, R. A. Mutagenesis of the amino-targeting signal of Saccharomyces cerevisiae 3-ketoacyl-CoA thiolase reveals conserved amino acids required for import into peroxisomes in vivo. J. Biol. Chem. 269: 7558-7563  (1994).

Carr, A. M., Schmidt, H., Kirchhoff, S., Muriel, W. J., Sheldrick, K. S., Griffiths, D. J., Nur Basmacioglu, C., Subramani, S., Clegg, M., Nasim, A., Lehmann, A. R. The rad16 gene of Schizosaccharomyces pombe: a homologue of the RAD1 gene of Saccharomyces  cerevisiae. Mol. Cell. Biol. 14: 2029-2040 (1994).

Spong, A., Subramani, S. Cloning and characterization of PAS5: A gene required for peroxisome biogenesis in the methylotropic yeast Pichia pastoris. J. Cell Biol. 123: 535-548 (1993).

Wendland, M., Subramani, S.  Presence of cytoplasmic factors functional in peroxisomal protein import implicates organelle-associated defects in several human peroxisomal disorders. J. Clin. Invest. 92: 2462-2468 (1993).

Subramani, S. Protein import into peroxisomes and biogenesis of the organelle. Annu. Rev. Cell Biol. 9: 445-478 (1993)

Marcus, S.L., Miyata, K.S., Zhang, B., Subramani, S., Rachubinski, R.A. and Capone, J.P. Diverse peroxisome proliferator activated receptors bind to the peroxisome proliferator responsive elements of the rat hydratase-dehydrogenase and fatty acyl-CoA oxidase genes but differentially induce expression. Proc Natl. Acad. Sci. USA., 90: 5723-5727 (1993).

Zhang, B., Marcus, S.L., Miyata, K.S., Subramani, S., Capone, J.P. and Rachubinski, R.A. Characterization of protein/DNA interactions within the peroxisome proliferator-responsive element of the rat hydratase-dehydrogenase gene. J. Biol. Chem.  268:12939-12945 (1993).

McCollum, D. M., Monosov, E. and Subramani, S. The pas8 mutant of Pichia pastoris exhibits the peroxisomal protein import deficiencies of Zellweger Syndrome cells - The PAS8 protein binds the COOH-terminal tripeptide peroxisomal targeting signal and is a member of the TPR protein family. J. Cell Biol.121: 761-774 (1993).

Wendland, M. and Subramani, S.  Cytosol dependent peroxisomal protein import in a permeabilized cell system.  J. Cell Biol. 120: 675-685  (1993).

Birkenbihl, R. and Subramani, S.  Cloning and characterization of rad21, an essential gene of Schizosaccharomyces pombe involved in DNA  double-strand-break repair.  Nucl. Acids Res. 20: 6605-6611  (1992).

Swinkels, B.W., Gould, S.J. and Subramani, S.  Targeting efficiencies of various permutations of the consensus C-terminal tripeptide peroxisomal targeting signal.  FEBS Lett. 305:133-136 (1992).

Blattner, J., Swinkels, B., Dörsam, M., Prospero, T., Subramani, S. and Clayton, C.  Glycosome assembly in trypanosomes: variations in the acceptable degeneracy of a C-terminal microbody targeting signal. J. Cell Biol., 119:1129-1136 (1992).

Zhang, B., Marcus, S.L., Sajjadi, F., Subramani, S., Alvares, K., Reddy, J.K., Rachubinski, R.A. and Capone, J.P.  Identification of a peroxisome proliferator response element upstream of the gene encoding rat peroxisomal enoyl-CoA hydratase/3-hydroxyacyl CoA dehydrogenase.  Proc. Natl. Acad. Sci. USA, 89: 7541-7545 (1992).

Subramani, S.  Mechanisms of protein transport into microbodies.  In Membrane Biogenesis and Protein Targeting, New Comprehensive Biochemistry, (W. Neupert and R. Lill, eds), Elsevier, The Netherlands, Ch 17, pp 221-229 (1992).

Jimenez, G., Yucel, J., Rowley, R. and Subramani, S.  The rad3+ gene of Schizosaccharomyces pombe is involved in multiple checkpoint functions and in DNA repair.  Proc. Natl. Acad. Sci. USA 89: 4952-4956 (1992).

Seaton, B.L., Yucel, J., Sunnerhagen, P. and Subramani, S.  Isolation and characterization of the Schizosaccharomyces pombe rad3+ gene which is involved in the DNA damage and DNA synthesis checkpoints.  Gene, 119: 83-89  (1992).

Distel, B., Gould, S.J., Voorn-Brouwer, T., van der Berg, M.  Tabak, H., and Subramani, S.  The carboxy-terminal tripeptide Serine-Lysine-Leucine of firefly luciferase is necessary but not sufficient for peroxisomal import in yeast.  New Biologist 4:157-165 (1992).

Gould, S.J., McCollum, D., Spong, A.P., Heyman, J.A. and Subramani, S.  Development of the yeast Pichia pastoris as a model organism for a genetic analysis of peroxisome assembly.  Yeast, 8: 613-628 (1992).

Walton, P.A., Gould, S.J., Rachubinski, R.A., Subramani, S. and Feramisco, J.R.  Transport of microinjected alcohol oxidase from Pichia pastoris into vesicles in mammalian cells:  Involvement of the peroxisomal targeting signal.  J. Cell Biol., 118: 499-508 (1992).

Walton, P.A., Gould, S.J., Feramisco, J.R. and Subramani, S.  Transport of microinjected proteins into peroxisomes of mammalian cells: Inability of Zellweger cell lines to import proteins with the SKL peroxisomal targeting signal.  Mol. Cell Biol. 12: 531-541 (1992).

Rowley, R., Subramani, S., and Young, P.G.  Checkpoint controls in Schizosaccharomyces pombe : rad1.  EMBO. J. 11:1335-1342 (1992).

Subramani, S.  Targeting of proteins into the peroxisomal matrix.  J. Memb.  Biol. 125: 99-106 (1992).

Sajjadi, F.G., Pasquale, E., and Subramani, S.  Identification of a new eph-related receptor tyrosine kinase gene from mouse and chicken that is developmentally regulated and encodes at least two forms of the receptor.  New Biologist 3: 769-778 (1991).

Swinkels, B.W., Gould, S.J., Bodnar, A.G., Rachubinski, R.A., and Subramani, S.  A novel cleavable peroxisomal targeting signal at the amino terminus of the rat 3-ketoacyl-CoA thiolase.  EMBO J. 10: 3255-3261 (1991).

Subramani, S.  Radiation-resistance in Schizosaccharomyces pombe.  Mol. Microbiol. 5: 2311-2314 (1991).

Subramani, S.  Peroxisomal targeting signals-the beginning and the end.  Curr. Sci., Indian Acad. Sci. 61: 28-32 (1991).

Hodge, V.J., Gould, S.J., Subramani, S., Moser, H.W. and Krisans, S.K.  Normal cholesterol synthesis in human cells requires functional peroxisomes.  Biochem. Biophys. Res. Commun. 181: 537-541 (1991).

Keller, G.-A., Krisans, S.K., Gould, S.J., Sommer, J., Wang, C.C., Schliebs, W.,  Kunau, W., Brody, S. and Subramani, S.  Evolutionary conservation of a signal that targets proteins to peroxisomes, glyoxysomes and glycosomes.  J. Cell. Biol. 114: 893-904 (1991).

Flagstad, T., Sundsfjord, A., Arthur, R.R., Pedersen, M., Traavik, T., and Subramani, S.  Amplification and sequencing of the control regions of BK and JC virus from human urine by polymerase chain reaction.  Virology 180: 553-560 (1991).

Gould, S.J. and Subramani, S.  Translocation of proteins into peroxisomes, in Intracellular Trafficking of Proteins (ed. C.J.Steer and J. Hanover), Cambridge University Press, Cambridge, England, Chapt. 20, pp 696-730 (1991).

Wright, R., Keller, G.-A., Gould, S.J., Subramani, S. and Rine, J.  Cell-type control of membrane biogenesis induced by HMG-CoA reductase overproduction.  New Biol., 2: 915-921 (1990).

Sundsfjord, A., Johansen, T., Flaegstad, T., Moens, U., Villand, P., Subramani, S. and Traavik, T.  At least two types of control regions can be found among naturally occurring BK virus strains.  J. Virol.,  64: 3864-3871  (1990).

Sunnerhagen, P., Seaton, B.L., Nasim, A. and Subramani, S.  Cloning and analysis of a gene involved in DNA repair and recombination, the  rad1  gene of  Schizosaccharomyces pombe.  Mol. Cell. Biol.,  10: 3750-3760  (1990).

Gould, S.J., Keller, G.-A., Schneider, M., Howell, S.H., Garrard, L.J., Goodman, J.M., Distel, B., Tabak, H. and Subramani, S.  Peroxisomal protein import is conserved between yeast, plants, insects and mammals.  EMBO J., 9: 85-90  (1990).

Gould, S.J., Krisans, S. Keller, G., and Subramani, S.  Antibodies directed against the peroxisomal targeting signal of firefly luciferase recognize multiple mammalian peroxisomal proteins.  J. Cell Biol.,  110: 27-34  (1990).

Zijlstra, M., Li, E., Sajjadi, F., Subramani, S. and Jaenisch, R.  Germ-line transmission of a disrupted ß2-microglobulin gene produced by homologous recombination in embryonic stem cells.  Nature,  342: 435-438 (1989).

Gould, S.J., Subramani, S. and Scheffler, I.E.  Use of the polymerase chain reaction for homology probing: isolation of partial cDNA or genomic clones encoding the iron-sulfur protein of succinate dehydrogenase from several species.  Proc. Natl. Acad. Sci. USA,  86:1934-1938  (1989).

Gould, S.J., Keller, G.-A., Hosken, N., Wilkinson, J. and Subramani, S.  A conserved tripeptide sorts proteins to peroxisomes.  J. Cell. Biol.,  108:1657-1664 (1989).

Cassill, J.A. and Subramani, S.  A naturally occurring deletion in the enhancer repeats of the human papovavirus BK optimizes early enhancer function at the expense of late promoter activity.  Virology,  170: 296-298 (1989).

Cassill, J.A., Deyerle, K.L. and Subramani, S.  Unidirectional deletion and linker scan analysis of the late promoter of the human papovavirus BK.  Virology,  169: 172-181 (1989).

Deyerle, K. and Subramani, S.  Human papovavirus BK early gene regulation in non-permissive cells.  Virology,  169: 385-396 (1989).

Deyerle, K., Sajjadi, F.G. and Subramani, S.  Analysis of the origin of DNA replication of the human papovavirus BK.  J. Virol.,  63: 356-365 (1989).

Seaton, B. and Subramani, S.  Transfer of chromosomal sequences onto plasmids by gene conversion.  In:  Gene Transfer and Gene Therapy, ICN-UCLA Symp. Mol. Biol., pp 417-430, Alan Liss Inc (1989).

Subramani, S.  Analysis of mitotic recombination in mammalian cells using SV40 and SV40-derived vectors.  Mutation Res., 220: 221-234 (1989).

Gould, S.J., Keller, G.-A. and Subramani, S.  Identification of peroxisomal targeting signals located at the carboxy terminus of four peroxisomal proteins.  J. Cell Biol., 107: 897-905 (1988).

Gould, S.J. and Subramani, S.  Firefly luciferase as a tool in molecular and cell biology.  Analyt. Biochem.,  175: 5-13 (1988).

Cassill, J.A. and Subramani, S.  The late promoter of the human papovavirus BK is contained within the early promoter enhancer region.  Virology,  166: 175-185 (1988).

Deyerle, K.L. and Subramani, S.   Linker scan analysis of the early regulatory region of the human papovavirus BK.  J. Virol., 62: 3378-3387 (1988).

O'Connor, D.T. and Subramani, S.  Do transcriptional enhancers also augment DNA replication?  Nucl. Acids Res., 16:11207-11222 (1988).

Subramani, S. and DeLuca, M.  Applications of the firefly luciferase as a reporter gene.  In:  Genetic Engineering - Principles and Practice (J. Setlow and A. Hollaender, Eds.), Vol. 10, pp 75-89, Plenum Press, New York, (1988).

Subramani, S. and Seaton, B.  Homologous recombination in mitotically dividing mammalian cells.  In:  ASM book on  Genetic Recombination  (R. Kucherlapati and G.R. Smith, Eds.), Chapt. 18, 549-573 (1988).

Gould, S.J., Keller, G.-A. and Subramani, S.  Identification of a peroxisomal targeting signal at the carboxy-terminus of firefly luciferase.  J. Cell. Biol.   105: 2923-2931 (1987).

Keller, G., Gould, S., DeLuca, M. and Subramani, S.  Firefly luciferase is targeted to peroxisomes in mammalian cells.  Proc. Natl. Acad. Sci. USA  84:3264-3268 (1987).

Rubnitz, J. and Subramani, S. Correction of deletions in mammalian cells by gene conversion.  Somatic Cell and Molecular Genetics.  13:183-190 (1987).

Deyerle, K.L., Cassill, J.A., and Subramani, S. Analysis of the early regulatory region of the human papovavirus BK. Virology  158: 181-193 (1987).

de Wet, J.R., Wood, K.V., DeLuca, M., Helinski, D.R. and Subramani, S.  Firefly luciferase gene:  Structure and expression in mammalian cells. Mol. Cell. Biol.   7: 725-737 (1987).

Peabody, D., Subramani, S. and Berg, P.  Effect of upstream reading frames on translation efficiency in SV40 recombinants.  Mol. Cell. Biol. 6: 2704-2711 (1986).

Rubnitz, J. and Subramani, S.  Extrachromosomal and chromosomal gene conversion in mammalian cells.  Mol. Cell. Biol.  6:1608-1614 (1986).

Subramani, S.  Rescue of chromosomal T-antigen sequences onto extrachromosomally replicating, defective simian virus 40 DNA by homologous recombination.  Mol. Cell. Biol.   6:1320-1325 (1986).

Subramani, S. and Rubnitz, J.  Expression vectors to study homologous recombination in mammalian cells.  Proceedings of Biotechnology Conference sponsored by Southern Petrochemical Industries Corporation, Madras, India (1985).

Rubnitz, J. and Subramani, S.  Rapid assay for extrachromosomal homologous recombination in monkey cells.  Mol. Cell. Biol.   5:529-537 (1985).

Subramani, S. and Rubnitz, J. Recombination events following transient infection and stable integration of DNA into mouse cells.  Mol. Cell. Biol.  5:659-666 (1985).

Rubnitz, J. and Subramani, S.  Minimum amount of homology for homologous recombination in mammalian cells.  Mol. Cell. Biol. 4:2253-2258 (1984).

Pratt, D.G. and Subramani, S.  Nucleotide sequence of the Escherichia coli xanthine-guanine phosphoribosyl transferase gene.  Nucl. Acids Res. 11:8817-8823 (1983).

Subramani, S. and Southern, P.  Analysis of gene expression using simian virus 40 vectors.  Anal. Biochem. 135:1-15 (1983).

Jolly, D.J., Esty, A.C., Subramani, S., Friedmann, T. and Verma, I.M.  Elements in the long-terminal repeat of murine retroviruses enhance stable transformation by thymidine kinase gene.  Nucleic Acids Res. 11:1855-1872 (1983).

Subramani, S. and Berg, P.  Homologous and non-homologous recombination in monkey cells.  Mol. Cell. Biol. 3:1040-1052 (1983).

Subramani, S. and Schachman, H.K.  Linkage between reactivity of sulfhydryl groups and subunit interactions in aspartate transcarbamoylase.  J. Biol. Chem. 257:12219-12223 (1982).

Subramani, S., Mulligan, R.C. and Berg, P.  Expression of the complementary DNA for mouse dihydrofolate reductase in simian virus 40 vectors.  Mol. and Cell. Biol. 1:854-864 (1981).

Subramani, S. and Schachman, H.K.  The mechanism of dissociation of aspartate transcarbamoylase by p-mercuribenzoate.  J. Biol.Chem. 256:1255-1262 (1981).

Fraley, R., Subramani, S., Berg, P. and Papahadjopoulos, D.  Introduction of liposome-encapsulated SV40 DNA into cells.  J. Biol. Chem. 255:10431-10435 (1980).

Subramani, S. and Schachman, H.K.  Mechanism of disproportionation of aspartate transcarbamoylase molecules lacking one regulatory subunit.  J. Biol. Chem. 255: 8136-8143 (1980).

Subramani, S.  Role of intersubunit bonding domains in aspartate transcarbamoylase.  Ph.D. Thesis, University of California, Berkeley (1979).

Subramani, S., Bothwell, M.A., Gibbons, I.,  Yang, Y.R. and Schachman, H.K.  Ligand-promoted weakening of intersubunit bonding domains in aspartate transcarbamoylase.  Proc. Natl. Acad. Sci. USA 74: 3777-3781 (1977).

Balasubramanian, D., Subramani, S. and Kumar, C.  Modification of a model membrane structure by embedded photochrome.  Nature 254: 252-254 (1975).

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