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--2020--
Plasma Cell Fate Is Orchestrated by Elaborate Changes in Genome Compartmentalization and Inter-chromosomal Hubs Bortnick, A., He, Z., Aubrey, M., Chandra, V., Denholtz, M., Chen, K., Lin, Y.C. and Murre, C. Cell Reports, 31(1)
Upon microbial challenge, human neutrophils undergo rapid changes in nuclear architecture and chromatin folding to orchestrate an immediate inflammatory gene program Denholtz, M., Zhu, Y., He, Z., Lu, H., Isoda, T., Döhrmann, S., Nizet, V. and Murre, C. Genes & Development, 34(1–17)
--2019--
Chromosome dynamics near the sol-gel phase transition dictate the timing of remote genomic interactions. Nature communications, 10(1), pp.1-13. Khanna, N., Zhang, Y., Lucas, J.S., Dudko, O.K. and Murre, C. Nature Communication, 10(1), 1-13
A B-Cell-Specific Enhancer Orchestrates Nuclear Architecture to Generate a Diverse Antigen Receptor Repertoire
Helix–loop–helix proteins and the advent of cellular diversity: 30 years of discovery
--2018--
Nuclear Architecture Controls the Timescales of Genomic Interactions
mTECs Aire on the side of caution
--2017--
Non-coding Transcription Instructs Chromatin Folding and Compartmentalization to Dictate Enhancer-Promoter Communication and T Cell Fate The E-Id Protein Axis Specifies Adaptive Lymphoid Cell Identity and Suppresses Thymic Innate Lymphoid Cell Development ccctc-binding Factor Translates Interleukin 2-and α-ketoglutarate-sensitive Metabolic Changes in T Cells into Context-dependent Gene Programs Comprehensive characterization of neutrophil genome topology
--2016--
Id3 Orchestrates Germinal Center B Cell Development Cellular and chromatin dynamics of antibody‐secreting plasma cells
--2015--
A common mechanism that underpins antibody diversification Murre, C. Cell 163, 1055-1056
The chromatin remodeler Brg1 activates enhancer repertoires to establish B cell identity and modulate cell growth Bossen, Murre, C.S., Chang, A.N., Mansson, R., Rodewald, H.R. and Murre, C. Nat. Immunol 16, 775-784
The E-Id protein axis modulates the activities of the PI3K-AKT-mTORC1-Hif1a and c-myc/p19Arf pathways to suppress innate variant TFH cell development, thymocyte expansion and lymphomagenesis Miyazaki. M., Miyazaki, K., Chen, S.Y., Chandra, V., Agata, Y., Chang, A., Kawamoto, H. and Murre, C. Genes Dev 29, 409-425
New roles for DNA cytosine modification, eRNA, anchors and superanchors in developing B cell progenitors Benner, C., Isoda, T and Murre, C. Proc. Natl. Acad. Sci USA 112, 12776-12781
--2014--
B cell super-enhancers and regulatory clusters recruit AID tumorigenic activity Qian, J., Wang, Q., Dose, M., Pruett N., Kieffer-Kwon, K.R., Resch, W., Liang, G., Tang, Z., Mathé, E., Benner, C., Duboi, W., Nelson, S., Vian, L., Oliveira, T.Y., Jankovic, M., Hakim, O., Gazumyan, A., Pavri, R., Awasthi, P., Song, B., Liu, G., Chen, L., Zhu, S., Feigenbaum, L., Staudt, L., Murre, C., Ruan, Y., Robbiani, D.F., Pan-Hammarstr?m, Q., Nussenzweig, M.C. and Casellas, R. Cell 18, 1524-1537
The 3-D trajectories adopted by coding and regulatory DNA elements: First-passage times and long-range genomic interactions Lucas JS, Zhang J, Dudko OS, Murre C Cell 158, 339-352
Id2 and Id3 maintain the regulatory T cell pool to suppress inflammatory disease Miyazaki M, Miyazaki K, Chen SY, Itoi M, Miller M, Lu L-F, Varki N, Chang A, Broide DH, Murre C Nat Immunol 15, 767-776
The establishment of B versus T cell identity Miyazaki K, Miyazaki M, Murre C Trends Immunol 35, 205-210
--2013--
Boosting lymphocyte production Murre C Immunity 38, 1081-1083
Nuclear location and the control of developmental progression Lin YC, Murre C Curr Opion Genet Dev 23, 104-108
A HESitant decision for T cells Bortnick A, Murre C Nat Immunol 14, 1209-1210
--2012--
Global changes in the nuclear positioning of genes and intra- and interdomain genomic interactions that orchestrate B cell fate Lin YC, Benner C, Mansson R, Heinz S, Miyazaki M, Miyazaki K, Chancera V, Bossen C, Glass CK, Murre C Nat Immunol 12,1196-1204
Chromatin topology and the regulation of antigen receptor assembly Bossen C, Mansson R, Murre C Annual Rev Immunol 30, 337-356
Positive intergenic feedback circuitry, involving EBF1 and FOXO1, orchestrates B-cell fate Mansson R, Welinder E, Ashber J, Lin YC, Benner C, Glass CK, Sigvardsson M, Murre C Proc Natl Acad. Sci USA 108, 17402-17407
--2011--
Multilineage priming of enhancer repertoires precedes commitment to the B and myeloid cell lineage in hematopoietic progenitors Mercer EM, Lin YC, Jhunjhunwala S, Dutkowski J, Flores M, Sigvardsson M, Ideker T, Glass CK, Murre C Immunity 35, 413-425
The opposing roles of the transcription factor E2A and its antagonist Id3 that orchestrate and enforce the naïve fate of T cells Miyazaki M, Rivera RR, Miyazaki K, Lin YC, Agata Y, Murre C Nat Immunol 12, 992-1001
E2A and HEB act in concert to induce the expression of FOXO1 in the common lymphoid progenitor Welinder E, Mansson R, Mercer EM, Bryder D, Sigvardsson M, Murre C Proc Natl Acad Sci USA 108, 17402-17407
CTCF-binding elements mediate control of V(D)J recombination Guo C, Yoon HS, Franklin A, Jain S, Ebert A, Cheng HL, Hansen E, Despo O, Bossen C, Vettermann C, Bates JG, Richards N, Myers D, Patel H, Gallagher M, Schlissel MS, Murre C, Busslinger M, Giallourakis CC, Alt FW Nature 477, 424-430
Transcription and recombination factories: Common features? Lucas JL, Bossen C, Murre C Curr Opin Cell Biol 23, 318-324
Ldb1, a new guardian of hematopoietic stem cell maintenance Welinder E, Murre C Nat Immunol 12, 113-114
CCCTC-binding factor (CTCF) and cohesin influence the genomic architecture of the Igh locus and antisense transcription in pro-B cells Degner SC, Verma-Gaur J, Wong TP, Bossen C, Iverson GM, Torkamani A, Vettermann C, Lin YC, Ju Z, Schulz D, Murre CS, Birshtein BK, Schork NJ, Schlissel MS, Riblet R, Murre C, Feeney AJ Proc Natl Acad Sci USA 108, 9566-9571
Factors and networks that underpin early hematopoiesis Mercer EM, Lin YC, Murre C Semin Immunol 5, 317-325
--2010--
A global network of transcription factors, involving E2A, EBF1 and Foxo1, that orchestrates B cell fate Lin YC, Jhunjhunwala S, Benner C, Heinz S, Welinder E, Mansson R, Sigvardsson M, Hagman J, Espinoza A, Dutkowski J, Ideker T, Glass CK, Murre C Nat Immunol 11, 635-643
Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities Heinz S, Benner C, Spann N, Bertolino E, Lin YC, Laslo P, Cheng JX, Murre C, Singh H, Glass CK Mol Cell 38, 576-89
--2009--
Chromatin architecture and the generation of antigen receptor diversity Jhunjhunwala S, van Zelm MC, Peak M, Murre C Cell 138, 435-448
Distinct roles for E12 and E47 in B cell specification and the sequential rearrangement of immunoglobulin light chain loci Beck K, Peak M, Ota T, Nemazee D. Murre C J Exp Med 206, 2271-2284
E2A proteins maintain the hematopoietic stem cell pool and promote the maturation of myelolymphoid and myeloerythroid progenitors Semerad CL, Mercer EM, Inlay MA, Weissman IL, Murre C Proc Natl Acad Sci USA 106, 1930-1935
Developmental trajectories in early hematopoiesis Murre C Genes Devel 15, 2366-2370
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