Pagkapol (Yhew) Pongsawakul
Graduate Student
Cell and Developmental Biology
Division of Biological sciences
Research topic: I am studying the molecular mechanism of the mammalian circadian clock and its interaction with the metabolic system. Specifically, I am interested in the regulation of the core clock component Cryptochromes (CRYs) and their mechanism in repressing cAMP signaling in hepatic gluconeogenesis.
Publications:
Zhang, E.E., Liu, Y., Dentin, R., Pongsawakul, P.Y., Liu A.C., Hirota, T., Nusinow, D.A., Sun, X., Landais, S., Kodama, Y., Brenner, D.A., Montminy, M.R., Kay, S.A. (2010) Cryptochrome mediates circadian regulation of cAMP signaling and hepatic gluconeogenesis. Nature Med. 16(10):1152-1156 PMID: 20852621
Zhang, E.E., Liu, A.C., Hirota, T., Miraglia, L.J., Welch, G., Pongsawakul, P.Y., Liu, X., Atwood, A., Huss 3rd , J.W., Janes, J., Su, A.I., Hogenesch, J.B., Kay, S.A. (2009) A genome-wide RNAi screen for modifiers of the circadian clock in human cells. Cell 139:199-210 PMID: 19765810 PMC: 2777987
