Higgins, R., Gendron, J. M., Rising, L., Mak, R., Webb, K., Kaiser, S. E., Zuzow, N., Riviere, P., Yang, B., Fenech, E., Tang, X., Lindsay, S. A., Christianson, J. C., Hampton, R. Y., Wasserman, S. A., Bennett, E. J. 2015. The Unfolded Protein Response Triggers Site-Specific Regulatory Ubiquitylation of 40S Ribosomal Proteins. Molecular Cell. 59:35-49. PDF

Theesfeld, C. L., Hampton, R. Y. 2013. Insulin-induced gene protein (INSIG)-dependent sterol regulation of Hmg2 endoplasmic reticulum-associated degradation (ERAD) in yeast. Journal of Biological Chemistry. 288:8519-30. PDF

Hampton, R. Y., Sommer, T. 2012. Finding the will and the way of ERAD substrate retrotranslocation.Current Opinion in Cell Biol. 24:460-6.PDF

Li, S., Spooner, R. A., Hampton, R. Y., Lord, J. M., Roberts, L. M. 2012. Cytosolic entry of Shiga-like toxin a chain from the yeast endoplasmic reticulum requires catalytically active Hrd1p. PLoS One. 7:e41119. PDF

Theesfeld, C. L., Pourmand, D., Davis, T., Garza, R. M., Hampton, R. Y. 2011. The sterol-sensing domain (SSD) directly mediates signal-regulated endoplasmic reticulum-associated degradation (ERAD) of 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase isozyme Hmg2. Journal of Biological Chemistry. 286:26298-307. PDF

Hampton, R. Y. 2011. San1-mediated quality control: substrate recognition "sans" chaperones. Molecular Cell. 41:2-3. PDF

Heck, J. W., Cheung, S. K., Hampton, R.Y. 2010. Cytoplasmic protein quality control degradation mediated by parallel actions of the E3 ubiquitin ligases Ubr1 and San1. Proceedings of the National Academy of Sciences (USA) 107:1106-11. PDF

Carroll, S. M., Hampton, R. Y. 2010. Usa1p is required for optimal function and regulation of the Hrd1p endoplasmic reticulum-associated degradation ubiquitin ligase. Journal of Biological Chemistry. 285:5146-56. PDF

Garza, R. M., Hampton, R. Y. 2009. Geranylgeranyl pyrophosphate (GGPP) is a potent regulator of HRD-dependent HMG-CoA reductase degradation in yeast. Journal of Biological Chemistry.284:35368-80. PDF

Sato, B.K., Schulz, D., Do, P.H., Hampton, R.Y. 2009. Misfolded membrane proteins are specifically recognized by the transmembrane domain of the Hrd1p ubiquitin ligase. Molecular Cell 34:212-22. PDF (1.2Mb)

Garza, R. M., Sato, B.K., Hampton, R. Y. 2009. In vitro analysis of Hrd1p-mediated retrotranslocation of its multispanning membrane substrate 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase. Journal of Biological Chemistry 284:14710-22. PDF (1.5Mb)

Hampton, R. Y., Garza, R. M. 2009. Protein quality control as a strategy for cellular regulation: lessons from ubiquitin-mediated regulation of the sterol pathway. Chemical Reviews 4:1561-74. PDF (600K)

Hampton, R. Y. 2008. A cholesterol toggle switch. Cell Metabolism 8:451-3. PDF (48K)

Federovitch, C.M., Jones, Y.Z., Tong, A.H., Boone, C., Prinz, W.A., Hampton, R.Y. 2008. Genetic and structural analysis of Hmg2p-induced endoplasmic reticulum remodeling in Saccharomyces cerevisiae. Molecular Biology of the Cell 19:4506-20. PDF (1.8Mb)

Bazirgan, O.A., Hampton, R. Y. 2008. Cue1p is an activator of Ubc7p E2 activity in vitro and in vivo. Journal of Biological Chemistry 283:12797-810. PDF (744k)

Chen, D., Gould, C., Garza, R., Gao, T., Hampton, R.Y., Newton, A.C. 2007. Amplitude control of protein kinase C by RINCK, a novel E3 ubiquitin ligase. Journal of Biological Chemistry 282:33776-87. PDF (704K)

Bazirgan, O.A., Garza, R.M., Hampton, R. Y. 2006. Determinants of RING-E2 fidelity for Hrd1p, a membrane-anchored ubiquitin ligase. Journal of Biological Chemistry 281:38989-9001. PDF (984K)

Sato, B.K., Hampton, R. Y. 2006. Yeast Derlin Dfm1 interacts with Cdc48 and functions in ER homeostasis. Yeast 23:1053-1064. PDF (843K)

Hampton, R. Y. 2005. Fusion-based strategies to identify genes involved in degradation of a specific substrate. Methods in Enzymology 399:310-323. PDF (119K)

Flury, I., Garza, R.M., Shearer, A.G., Rosen, J., Cronin, S. Hampton, R. Y. 2005. INSIG: a broadly conserved transmembrane chaperone for sterol-sensing domain proteins. EMBO Journal 24:3917-3926. PDF (456K)

Federovitch, C.M., Ron, D., Hampton, R. Y. 2005. The dynamic ER: experimental approaches and current questions. Current Opinions in Cell Biology 17:409-414. PDF (308K)

Garza, R.M., Hampton, R. Y. 2005. Cell biology: sterol sensor comes up for air. Nature 435:37-38. PDF (188K)

Bazirgan, O.A., Hampton, R. Y. 2005. Cdc48-Ufd2-Rad23: the road less ubiquitinated? Nature Cell Biology 7:207-209. PDF (284K)

Shearer, A.G., Hampton, R. Y. 2005. Lipid-mediated, reversible misfolding of a sterol-sensing domain protein. EMBO Journal 24:149-159. PDF (304K)

Ron, D, Hampton, R. Y. 2004. Membrane biogenesis and the unfolded protein response. Journal of Cell Biology 167:23-25. PDF (96K)

Shearer, A.G., Hampton, R. Y. 2004. Structural control of endoplasmic reticulum-associated degradation: effect of chemical chaperones on 3-hydroxy-3-methylglutaryl-CoA reductase. Journal of Biological Chemistry 279:188-196. PDF (384K)

Hampton, R. Y. 2003. IRE1: a role in UPREgulation of ER degradation. Developmental Cell 4:144-146. PDF 92K)

Hampton, R. Y. 2002. ER-associated degradation in protein quality control and cellular regulation. Current Opinions in Cell Biology 14:476-482. PDF (188K)

Hampton, R. Y. 2002. Proteolysis and Sterol Regulation. Annual Reviews of Cell and Developmental Biology 18:345-78. PDF (464K)

Bays, NW, Hampton RY. 2002. Cdc48-ufd1-np14: stuck in the middle with ub. Current Biology 12: R366-71. PDF (488K)

Cronin, S. R., Rao, R., Hampton, R. Y. 2002. Cod1p/Spf1p is a P-type ATPase involved in ER function and CA2+ homeostasis. Journal of Cell Biology 157:1017-1028. PDF (476K)

Bays, N. W., Wilhovsky, S. K., Goradia, A., Hodgkis-Harlow, K., Hampton, R. Y. 2001. HRD4/NPL4 Is Required for the Proteasomal Processing of Ubiquitinated ER Proteins. Molecular Biology of the Cell 12:4114-28. PDF (692K)

Gardner RG, Shearer AG, Hampton RY. 2001. In vivo action of the HRD ubiquitin ligase complex: mechanisms of endoplasmic reticulum quality control and sterol regulation. Molecular Cell Biology 21:4276-91. PDF (840K)

Gardner, R., Shan, H., Matsuda, S., and R. Hampton. 2001. An oxysterol-derived positive signal for 3-hydroxy-3-methylglutaryl-CoA reductase degradation in yeast. Journal of Biological Chemistry 276: 8681-8684. PDF (652K)

Bays, N., Gardner, R., Seelig, L., Joazeiro, C., and R. Hampton. 2001. Hrd1p/Der3p is a membrane-anchored ubiquitin ligase required for ER-associated degradation. Nature Cell Biology 3:24-29. PDF (355K)

Gardner, R., Swarbrick, G., Bays, N., Cronin, S., Wilhovsky, S., Seelig, L., Kim, C., and R. Hampton. 2000. Endoplasmic reticulum degradation requires lumen to cytosol signaling: transmembrane control of Hrd1p by Hrd3p. Journal of Cell Biology 151:69-82. Full Text PDF (688K)

Wilhovsky, S., Gardner, R., and R. Hampton. 2000. HRD gene dependence of endoplasmic reticulum degradation. Molecular Biology of the Cell 11:1697-1708. Full Text PDF (428K)

R. Hampton. 2000. ER stress response: getting the UPR hand on misfolded proteins. Current Biology 10:R518-521. Full Text

R. Hampton. 2000. Cholesterol homeostasis: ESCAPe from the ER. Current Biology 10:R298-301. Full Text PDF

Cronin, S., Khoury, A., Ferry, D., and R. Hampton. 2000. Regulation of HMG-CoA reductase degradation requires the P-type ATPase Cod1p/Spf1p. Journal of Cell Biology 148:915-924. Full Text PDF (324K)

Gardner, R. and R. Hampton. 1999. A 'distributed degron' allows regulated entry into the ER degradation pathway. Embo 18:5994-6004. Full Text PDF (332K)

Gardner, R. and R. Hampton. 1999. A highly conserved signal controls degradation of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase in eukaryotes. Journal of Biological Chemistry 274:31671-31678. Full Text PDF (353K)

Gardner, R., Cronin, S., Leder, B., Rine, J., and R. Hampton. 1998. Sequence determinants for regulated degradation of yeast 3-hydroxy-3-methylglutaryl-CoA reductase, an integral endoplasmic reticulum membrane protein. Molecular Biology of the Cell 9:2611-2626. Full Text PDF (553K)

Hampton, R. and H. Bhakta. 1997. Ubiquitin-mediated regulation of 3-hydroxy-3-methylglutaryl-CoA reductase. Proc. Natl. Acad. Sci. USA 94:12944-12948. Full Text PDF (314K)

Hampton, R., Gardner, R., and J. Rine. 1996. Role of 26S proteasome and HRD genes in the degradation of 3-hydroxy-3-methylglutaryl-CoA reductase, an integral endoplasmic reticulum membrane protein. Mol.Biol. Cell 7:2029-2044. Abstract

Hampton, R, Dimster-Demk. D., and J. Rine. 1996. The biology of HMG-CoA reductase: The pros of contra-regulation. Trends Biochem. Sci. 21:142-145.

Hampton, R., Koning, A., Wright, R., and J. Rine. 1996. In vivo examination of membrane protein localization and degradation with green fluorescent protein. Proc. Natl. Acad.Sci. USA 93 (2):828-33.

Hampton, R. and J. Rine. 1994. Regulated degradation of HMG-CoA reductase, an integral membrane protein of the endoplasmic reticulum, in yeast. J. of Cell Biology 125: 299-312.