The Halpain lab is broadly interested in cytoskeletal mechanisms that regulate neural circuit development and plasticity, and the survival potential of neurons under stress. We use a variety of technical approaches, but mainly cellular and subcellular imaging, to investigate signaling events that support neuronal morphology and its response to changes in neural activity. High resolution fluorescence microscopy, time-lapse subcellular imaging, and quantification of the dynamic
reorganization of protein complexes involving actin filaments and microtubules are among the key tools applied to our studies of rodent brain and human iPSC cultures. Our studies are fundamentally relevant to several neurological conditions, including stroke, autism, and bipolar disorder.
Our work is sponsored by the National Institutes of Health. Our images have been featured worldwide. We train undergraduates, graduate students, and postdoctoral colleagues in our laboratory.
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