Forbes Lab
Structure and Function of the Eukaryotic Nucleus

Research Projects

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Division of Biological Sciences



 The focus of our research is the eukaryotic nucleus: its structure and function.  A primary area of interest is the nuclear pore, a large macromolecular  envelope. All communication between the nucleus and cytoplasm occurs  through the nuclear pore: the pore actively imports proteins needed for DNA  replication, RNA transcription;and gene control, while excluding cytoplasmic  proteins. The pore also must export messenger RNA, tRNA, snRNAs, and  ribosomal precursors. With respect to the nuclear pore, we are studying: (1)  the mechanism of nuclear transport, (2) the structure and component proteins  of the pore, and (3) reconstitution of the nuclear pore in vitro.


University of California, San Diego
Section of Cell and Developmental Biology
Division of Biological Sciences
9500 Gilman Drive
Pacific Hall, Room 2128
La Jolla, CA 92093-0347

lab: (858) 534-6346 fax: (858) 534-0555