Division of Biological
The focus of our research is the
eukaryotic nucleus: its structure and function. A
primary area of interest is the nuclear pore, a large macromolecular
envelope. All communication between the nucleus and
cytoplasm occurs through the nuclear pore: the pore
actively imports proteins needed for DNA replication,
RNA transcription;and gene control, while excluding
cytoplasmic proteins. The pore also must export
messenger RNA, tRNA, snRNAs, and ribosomal precursors.
With respect to the nuclear pore, we are studying: (1)
the mechanism of nuclear transport, (2) the
structure and component proteins of the
pore, and (3) reconstitution of the nuclear pore in vitro.